Publications of Cornell University Medical College: Studies from the Departments of Pathology, Bacteriology and Immunology, Public Health & Preventive Medicine, Volumes 5-6

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Page 107 - In conclusion, I wish to express my thanks to the members of the Council for their loyal support; Mr.
Page 6 - The exact nature of the disturbance of nitrogenous metabolism which is responsible for the clinical manifestations of the toxemia of pregnancy is a failure of oxidizing capacity on the part of the liver. For this reason, the proteid derivatives, principally amidoacids and ammonia, which are normally combined by the liver into urea, are no longer combined but circulate free in the blood in poisonous form, and are to some extent excreted by the kidneys.
Page 14 - ... tissue injected a large amount of extraneous material, as, for example, bile, which previously was included and which undoubtedly influenced the qualities of the serum. The next experiment was made with a nucleoproteid antipancreatic serum. Pearce 18 has found that an antiserum from the pancreas " did not produce haemoglobinuria but a persistent albuminuria with fatty degeneration of the kidney. The strongest dose given caused also well-marked focal necroses of the liver with evidence of red-blood-cell...
Page 6 - With pronounced diminution in the protein metabolism (as shown by the total nitrogen in the urine!, there is usually, but not always, and therefore not necessarily, a decrease in the absolute quantity of ammonia eliminated. A pronounced reduction of the total nitrogen is, however, always accompanied by a relative increase in the amrooni» nitrogen, provided that the food is not such as to yield an alkaline ash.
Page 18 - September 1), gives the results of therapeutic experiments made with a specific serum prepared by separating the nucleoproteids and thyreoglobulin from the human thyroid gland and injecting these bodies into the peritoneal cavities of rabbits, dogs, or sheep. The inoculations are continued at intervals of five or six days for about six weeks and the animals are then bled from the carotid. The serum thus obtained is presumed to contain an antibody or cytotoxin which is specific in its action on the...
Page 24 - ... too few to be recognizable as belonging to the transplanted nodule. This suggestion appears the more plausible since these observers state that the transformation of tissue cells into tumor cells is noted chiefly about slowly-growing tumors which are not well encapsulated. Such slowly-growing tumors, however, are less suitable for revealing the true capacities of the cells for independent existence. They admit, also, that in more rapidly-growing tumors the chief part of the growth arises from...
Page 37 - Fehling: Die Pathogenese und Behandlung der Eklampsie im lichte der heutigen Anschauung.
Page 8 - These changes indicate chiefly deficient oxidation of proteid derivatives. Instead of urea, uric acid, ammonia, leucin and tyrosin and other unoxidized proteid radicles appear in the urine and instead of sulphates there are unoxidized sulphur compounds. As leucin...
Page 4 - TORREY. (From the Department of Experimental Pathology, Loomis Laboratory, Cornell University Medical College, New York.
Page 2 - ... have strong haemolytic and haemagglutinative properties in vitro; however, they do not always show the same behavior in vivo. Nevertheless, he finds that sera prepared in this way from pancreas and adrenal may cause degenerative changes in the liver and kidney. He says: "Some of these cytotoxic sera have no effect upon organs for which they are supposed to have a morphological affinity, but exert a powerful lytic action on other cells," and he concludes that with the exception of the nephrotoxin...

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